Category Archives: News

The revolution of cosmetics: new success of the fluidnatek technology for the production of ultrathin fibers by electrospinning

Innovative cosmetic products co-developed by CSIC and Bioinicia: more sustainable and composed only of active ingredients, without excipients and additives: Pure Cosmetics is here!

Patented technology is able to encapsulate compounds in ultra-thin fibers that melt on contact with the skin.

These innovative cosmetic products based on ultra-thin fibers are already available on the market.

Spanish Council for Scientific Research – CSIC, the network of the most excellent research institutes in Spain, together with the company Bioinicia, CDMO of the Bioinicia Group specialized in the development and manufacture of medical, pharmaceutical and cosmetic products using ultrathin fibers (electrospinning) and particles  (electrospraying), have jointly patented a technology that makes it possible to create cosmetic products, composed entirely of active ingredients with proven efficacy in vivo tests. Using this technique, the ingredients are encapsulated in ultra-thin, water-soluble fibers, which in turn are also composed of cosmetic substances. The technology makes it possible to dispense with all the excipients, conservatives, and additives of conventional cosmetics, while maximizing the penetration and efficacy of the active ingredients.

All these cosmetic products based on highly innovative electrospun fiber-based membranes, which achieve a higher penetration of active ingredients than other conventional cosmetic products, are being manufactured excellently using Fluidnatek electrospinning equipment. More specifically, the process was successfully developed and scaled up using a Fluidnatek LE-500 platform (pilot-production plant), while full-scale manufacturing is taking place using Fluidnatek HT industrial line for mass production.

Using this technology, CSIC and Bioinicia -through its brand Bioinicia Cosmetics– have developed a new line of 100% natural and vegan cosmetic products for the care and improvement of skin health. “They are composed solely of bioactive ingredients, creating a new generation of cosmetics: Pure Cosmetics”, says Dr. José María Lagarón, CSIC researcher at the Institute of Agrochemistry and Food Technology (IATA) in Valencia, Spain.

Technology is based on the electro-hydrodynamic processing of the technical effect Fiber Boost by electrospinning, which increases the penetration of the active ingredients by more than ten times. These fibers are 100 times thinner than the thickness of a human hair and melt instantly on contact with the skin, providing a clearly noticeable cosmetic effect in just three seconds of application.

“Its double action mechanism is the key”, says Dr. José María Lagarón. “The ultra-thin fibers adhere and adapt perfectly to the skin’s relief and deliver the active ingredients more homogeneously and effectively. In fact, we have measured that some bioactives penetrate up to 10 times more than in conventional liquid formulations”, he explains. “In addition, the active ingredients are protected within the fibers, embedded in the fibers, keeping all their properties intact and maximizing their efficacy”, he says.

Triple conquest of sustainability in cosmetics

While maximizing the penetration and efficacy of active ingredients, the technology also makes it possible to dispense with all the excipients, conservatives and additives that are necessary to stabilize conventional cosmetics, but which nevertheless provide no benefit to the consumer. “This entails a triple conquer when it comes to sustainability in cosmetics”, Dr. Lagarón points out.

Success of Fluidnatek electrospinning technology

Once again, another real, commercially available electrospun product is manufactured on a large scale using Fluidnatek electrospinning equipment. In this case in the field of cosmetics, although electrospun products have previously been developed in the biomedical, pharmaceutical and filtration fields using Fluidnatek electrospinning platforms. It is a further demonstration of the reliability, consistency, and scalability of Fluidnatek technology to produce nanofiber-based products with a wide range of materials and solvents. Fluidnatek is therefore proud to celebrate this milestone, and we wish Bioinicia and CSIC every success in this new venture in the cosmetics sector.

We invite you to our webinar “Elastin-Based Nanofibers for Advanced Wound Care: Innovation Driven by Electrospinning”

From Bioinicia Fluidnatek, we would like to invite you to our highly informative Webinar in collaboration with the German biomedical company, matrihealth.

Date: November 22nd, 2023.
Time: 5 p.m. CET / 11 a.m. ET / 8 a.m. PT.
Register on this link:


The extracellular matrix (ECM) is composed of a fibrous network of structural proteins that enhance tissue mechanical properties and offer cellular support. Elastin, a pivotal structural protein within the ECM, is the main component of elastic fibers, and responsible for the elasticity and resilience of tissues and organs. However, elastin is not replenished throughout life, leading to tissue degeneration and loss of function. In response to this challenge, we have devised biomaterials with customizable mechanical properties as a promising solution to counteract the age- and injury-related decline in skin function. We isolated and processed elastin through a proprietary and industrially scalable process to develop composite elastin/collagen nonwoven materials using electrospinning and chemical crosslinking. Processed elastin was successfully integrated into electrospun nonwovens in high amounts up to 90%. Elastin significantly reduces the elastic modulus of the nanofibers while increasing the fleece porosity. These fully absorbable materials exhibited non-cytotoxicity, low irritative potential, and proved to be excellent scaffolds for cell culturing. Furthermore, endotoxin levels for processed elastin and cross-linked nonwovens were both found to be below 10 EU/g and 5 EU/g, respectively, and the material does not cause averse tissue reactions after implantation. Our work has yielded a versatile platform for the industrial-scale, cost-effective production of elastin and tunable nonwoven materials produced by electrospinning for a wide range of biomedical applications.

About the expert

Tobias Hedtke is the CTO and co-founder of matrihealth. He studied biochemistry at Martin Luther University Halle-Wittenberg and received his Master’s degree in 2016. Since 2017, he has been a research associate at the Fraunhofer Institute for Microstructure of Materials and Systems IMWS in Halle (Saale), Germany specializing in the development and characterization of protein-based biomaterials. He is pursuing his PhD in elucidating the molecular structure of elastin and is using these new insights to develop novel elastin-based biomaterials. Since October 2022, he has been responsible for technology, production, and product development at matrihealth GmbH.

About matrihealth

matrihealth GmbH is a life science start-up founded in October 2022 as a spin-off from the Fraunhofer Institute for Microstructure of Materials and Systems IMWS in Halle (Saale), Germany. matrihealth specializes in the isolation and processing of elastin, which will be sold as a raw material in the R&D, cosmetics, nutrition, and medical market sectors. For this purpose, the matrihealth team has developed a proprietary and industrially scalable process that enables the cost-effective production of this high-quality raw material. Another focus of matrihealth is the development of biomaterials for the treatment of complex and chronic wounds, which will be further developed into wound treatment products in the future.

We look forward to welcoming you.

Bioinicia Fluidnatek – Sponsors at Berlin Symposium on Tissue Regeneration 2023!

We are excited to announce that Bioinicia Fluidnatek will be present at the BSRT – Tissue Regeneration Symposium 2023 in Berlin, Germany, as a sponsor of the event from 6th to 8th December, 2023. We will be happy to attend anyone interested in electrospinning for biomedical applications.

This event is a unique opportunity to acquire new knowledge in various disciplines related to tissue regeneration from expert speakers who will discuss the challenges facing regenerative medicine with a focus on enhancing tissue regeneration.

We are excited to share ideas, learn from other experts and discuss what we have learned, network with leaders and innovators and share the latest developments of our premium equipments in electrospinning and electrospraying techniques, which produce electrospun materials, for biomedical research.

We look forward to seeing you there, on the Hallway!


Bioinicia Fluidnatek and The Electrospinning Company further strengthen their collaboration.

Bioinicia Fluidnatek and The Electrospinning Company Ltd. collaborate to provide the medical device industry with unmatched levels of process development and manufacturing capability for electrospun materials and implantable devices. ELECTROSPINNING uses the FLUIDNATEK® electrospinning and electrospraying equipment platform for its biomaterial development and for its custom design, development, and manufacturing services.

The Electrospinning Company facility & Fluidnateck Equipment

FLUIDNATEK & ELECTROSPINNING have been working together since 2017, combining expertise in polymer chemistry and biomaterial design with mechanical and software engineering to deliver innovative, safe, and reliable solutions to medical device product developers. ELECTROSPINNING operates a series of FLUIDNATEK electrospinning machines in its class VII cleanroom facilities which FLUIDNATEK supports with a full maintenance and calibration service to ensure compliance with medical device quality standards.

The Companies are strengthening their partnership with continual improvement projects to customize electrospinning platforms to specific product requirements and to develop data collection and analytical tools for traceability under the ISO13485 requirements for medical device manufacturing and statistical process control. In addition, FLUIDNATEK is supporting ELECTROSPINNING with the development of automated production processes to improve consistency and cost as volumes scale.

Amongst its FLUIDNATEK’s electrospinning equipment, ELECTROSPINNING is using FLUIDNATEK’s BioTubing platform specifically engineered for the production of electrospun tubular structures to be used for structural heart and peripheral vascular interventions. This technology platform address the need for suture-less bonding of medical textiles to a wide range of stent and occluders. The combination of state-of-the-art equipment by FLUIDNATEK and a decade of experience in electrospun non-woven biomaterials by ELECTROSPINNING unlocks the development and manufacturing of a new generation of medical devices now and in the future.

The Electrospinning Company R&D Scietists

About Bioinicia Fluidnatek

The Bioinicia Group based in Valencia, Spain, specializes in electrospinning & electrospraying processes with a focus on pharmaceuticals (drug delivery platforms), biomedical, cosmetics, filtration, and nutraceuticals. Under the Fluidnatek® and Spinbox® brand names, Bioinicia Fluidnatek develops and commercializes electrospinning equipment with a high degree of specialization for the pharmaceutical and biomedical fields.

About The Electrospinning Company

The Electrospinning Company, based on the Harwell Innovation Campus near Oxford in the UK, designs, develops, and manufactures nanofibrous biomaterials for implantable medical devices and regenerative medicine applications. The Company has four technology platforms: Mimetix® resorbable membranes; Kalyptix® non-resorbable membranes; Symatix® bio-synthetic membranes and Coating of medical textiles onto metal and non-metal 3D structures. It offers a range of proprietary materials as well as tailored contract development and manufacturing services, all in validated cleanrooms under ISO 13485 accreditation.