Fluidnatek LE-50 G2
The Fluidnatek LE-50 G2 is a lab-scale electrospinning and electrospraying machine, ideal for researchers developing new materials and formulations, prototype development and feasibility studies (e.g. proof of concept) requiring high levels of process control. Built to fit into small lab spaces, its ergonomic design and ease of use allow for an efficient workflow.
Further to the flexibility and versatility of research offered, the tight process control provided by the Fluidnatek LE-50 G2 enables consistency and reproducibility every time, what is absolutely crucial to conduct reliable research, leading to rock solid conclusions.
Environmental control is critical for achieving consistent and reproducible proof-of-concept results. The Fluidnatek LE-50 G2 can be fitted with an Environmental Control Unit (ECU) that provides heating, cooling, drying, and humidifying functions, with ranges of 18-45ºC for temperature and 10-80% for relative humidity, with a great stability below +/-3% with respect the setpoint desired for the relative humidity.
The Fluidnatek LE-50 G2 is an ideal nanofiber electrospinning machine for projects that require advanced, versatile functions and precise process control, meaning whenever a serious, professional research (with consistent and reproducible results) is intended to be conducted.
Its compact benchtop design makes it suitable for laboratories with limited space.
The Fluidnatek LE-50 G2 benchtop laboratory electrospinning machine is ideal for investigating new materials and formulations, prototype development, and small-scale manufacturing activities that require a high level of process control. Its ergonomic layout and intuitive interface help streamline both research and production workflows.
Advanced functions that give users extensive process flexibility include:
| Feature | LE-50 G2 Specification | Why It Matters |
|---|---|---|
| Equipment Type | Modular benchtop electrospinning and electrospraying lab-scale system | A wide variety of optional upgrades (add on), items and functionalities, can be added to the machine configuration at any time, being the majority of the optional upgrades Plug & Play, thus it offers a great flexibility to researchers making their lives easy too. |
| Research Focus | Designed for advanced research, education, and early-stage material development | Advanced research requires a sophisticated engineering behind, supporting not only multidisciplinary experimentation and process exploration, but also a tight process control providing an excellent performance, what leads to consistency and reproducibility every time. This is a must whenever a rock solid research report or paper is intended to be done. |
| Experimental Flexibility | Plug & Play modular upgrades, including multiple collectors, coaxial and triaxial spinning, multi-emitter spinning injectors, needle-based and needle-less electrospinning technologies, fully independent dual spinning ability, electro-blow spinning, standard syringe pumps and high-pressure syringe pumps, environmental control, amongst other possible upgrades | Allows researchers to expand experimental capabilities, to try different machine configurations and spinning arrangements, to test a broad range of polymers and solvents, to have a tight control from all parameters governing the electrospinning process, and to investigate complex electrospun or electrosprayed material structures with one single electrospinning platform. |
| Construction | Stainless steel, aluminum, and glass frame | Supports chemically resistant, durable, and easy-to-clean laboratory operation. |
| Footprint (Fluidnatek LE-50 G2) | ~100 kg | 920 mm x 780 mm x 1000 mm | Optimized for small to medium laboratories requiring a compact yet versatile research platform. |
| Voltage Range | Positive high-voltage for emitter: adjustable +1 to +30 kV. Negative high-voltage for collector: up to adjustable -1 to -10 kV | Ensures a stable environment for advancing electrospinning and electrospraying techniques. By fine-tuning both the positive emitter voltage and the negative collector voltage, it significantly enhances the process stability and the fiber (or particle) deposition onto the collector. |
| User Interface | 7″ touch-screen control (214 mm × 158 mm) | All process parameters are controlled by the user via touch-screen interface. The same screen also shows up the Taylor cone image (provided that the visualization system is upgraded). |
| Remote communication | Integrated Ethernet module | It allows a simple, quick remote communication with the electrospinning equipment for fast diagnostics and/or software upgrades. |
| Actively regulated Exhaust System | Smart exhaust fan for solvent vapor extraction | The actively regulated exhaust system is self-regulated and in permanent communication with the climate control unit, creating a slight negative pressure in the experimental chamber, and automatic shutdown if ventilation fails — required when using any Fluidnatek climate control unit. |
| Environmental Control | Two options for temperature and humidity control: ECU (Environmental Control Unit) or DHU (Drying-Heating Unit) | All materials are sensitive to environmental conditions, temperature (T) and relative humidity (RH). Variations in temperature or humidity when processing with electrospinning will result in substantial changes in the outcome obtained (electrospun or electrosprayed material), particularly in the morphology, the homogeneity and the uniformity. Therefore, a robust, stable climate control is a must for consistency and reproducibility of the experiments. The Drying-Heating Unit or DHU enables heating and/or drying, intended basically to reduce the relative humidity (RH) in the experimental chamber; it reduces chamber humidity (down to 25% RH at 25°C, or below 10% RH at 45°C) and raises temperature (up to 45°C ±1°C). Whereas the Environmental Control Unit or ECU enables all degrees of freedom in climate control: heating, cooling, drying, and humidifying, thus reaching the setpoint of environmental conditions required in the experimental chamber regardless the lab environmental conditions outside. It provides a great long-term stability for the electrospinning environmental conditions, both in temperature (±1°C) and relative humidity (±3%). Consistent results every time! |
| Spinning Modes and Injectors | Single-phase, coaxial and triaxial spinning; multi-emitter spinning heads: 5 or 10 emitters/needles each; also needle-less Slit Injector | The different spinning modes and spinning injectors available, enable researchers to generate multiple material structures with different phases and properties (e.g. single-phase, core-shell, multiple core-shell…). Likewise, the multi-emitter spinning injectors with several emitters/needles increase the process throughput, at the time the process can be scaled-up more to some extent. Furthermore, the Slit Injector allows to also test needle-less electrospinning technology, everything in one single electrospinning platform. |
| Electro-blow Spinning | Gas-assisted electrospinning | Enables gas-assisted electrospinning (known as electro-blow spinning), facilitating targeted deposition on less conductive collectors, where the solely electrostatic force is not enough for a proper fiber deposition. This process usually increases throughput, and in some cases prevents solution build-up at the needle tips when processing high-viscosity materials. |
| Collector Types | Static flat plate (tool-free removal; orientable vertically or horizontally). Rotating collectors: Drums, mandrels, and disc collectors available as optional upgrades | The system supports a wide range of workflows—including random, aligned, tubular, and particle deposition—by allowing for the quick and seamless installation of specialized collectors tailored to each specific application. |
| Emitter–Collector Distance | 0–350 mm (using the flat plate collector) and 0-300mm (using the standard drum collector) | The spinning distance (distance from the emitter to the collector) is a process parameter that affects the result obtained. The spinning distance must be optimized to get a stable jet and good solvent evaporation. The spinning distance range provided by the Fluidnatek LE-50 G2 electrospinning-electrospraying platform is wide enough to cover nearly the needs of all applications. |
| Run Time | Short or long batches | Gives you the flexibility to move from quick exploratory runs to longer development cycles (24 hours or more if needed). |
| Fiber Diameter Range | Typical fiber/particle diameters: 20 nm to 10 µm, dependent on material, formulation, and process parameters | Lets you cover a wide range of fiber and particle sizes and morphologies (including porosity), for different applications and process needs. |
| Solution Feeding System | Up to 3 standard syringe pumps, or up to 2 high-pressure twin-channel syringe pumps. Batch volume: 1–180 mL (3 standard syringe pumps) or 1–560 mL (2 high-pressure twin-channel pumps) | Syringe pumps are a good method to dispense the solution in electrospinning equipment. Furthermore, high-pressure syringe pumps with a higher linear force allow for the precise feeding of solutions, including those with high viscosities. |
| Solution feeding without tubing | Tubeless solution feeding system | When using tubing, it always unavoidably contains a dead volume (solution wastage). When using expensive materials, the solution wastage results in substantial extra cost. The Fluidnatek tubeless solution feeding system avoids the solution flowing through the tubing, therefore eliminating or minimizing dramatically the solution wastage. |
| Heating of solutions | Solution heating device | Very viscous solutions are hardly processable due to their huge viscosity. Sometimes, such solutions may reduce significantly the viscosity by increasing the temperature, meaning applying heat to the solution. The solution heating device, to be used in combination with the tubeless solution dispensing system, increases the temperature of the solution intended to be run from room temperature up to 120ºC, so that the solution becomes more fluid and can be processed. |
| Process Homogeneity | Automated scanning emitter motion with adjustable, precise linear speed and stroke length | Adjustable, precise back-and-forth spinning injector movement enables a higher homogeneity of electrospun fiber deposition across the collector. |
| Field deflectors | Customizable field deflectors for spinning injectors | In a multi-jet environment when processing with electrospinning or electrospraying, electrostatic forces cause repulsion between the jets, resulting this in turn into material wastage and uneven fiber deposition. The field deflectors modify the electrical field and minimize the repulsion effect, thus minimizing the material wastage and contributing to even fiber deposition, higher homogeneity. Geometry and dimensions of the field deflectors can be adapted for each specific process. |
| Solvent-Gas-Jacket System | System that regulates the flow of solvent-saturated gas around the emitter tips to help minimize drying and reduce the risk of needle blockage | When using volatile solvents, the jet tends to solidify at the tip of the emitter/needle, affecting or even blocking the process. The Fluidnatek solvent-gas-jacket system enable a more stable electrospinning/electrospraying process for solutions with volatile solvents, minimize drying and reduce the risk of needle blockage. |
| Fully independent Dual Spinning | Secondary independent spinning stage for dual spinning | Two materials can be deposited independently and simultaneously onto a rotating collector to create hybrid structures (this is called dual spinning). This setup enables the integration of different components, by running two different solutions and applying totally independent process parameters to both (voltage, spinning distance, linear speed for injector, stroke length for injector), into a single structure, expanding the limits of material research. |
| Process Monitoring | Taylor cone visualization system with video recording function, plus temperature and relative humidity sensors | The Taylor cone visualization system enables real-time monitoring of the Taylor cone; its shape and stability serve as critical indicators of process consistency, thereby accelerating research. Similarly, the integrated temperature and relative humidity sensors track environmental conditions within the chamber, which significantly influence the properties of electrospun or electrosprayed materials (that’s why a robust, accurate climate control unit is that critical in electrospinning and electrospraying). |
| Advanced software functionalities | Advanced data collection, and process automation | Collection of process data, variables and equipment signals is key to provide evidence of having a consistent process that can be reproduced the same way every time. The Fluidnatek Process Data Hub tool enables the collection of 20+ process parameters and equipment signals, displaying data and graphs in a personalized dashboard, for a complete data-driven research. Likewise, process automation allows to eliminate the human intervention, while the equipment is able to run automatically a determined process that has been previously programmed, step by step, even with process parameters varying overtime. This is provided by the Fluidnatek Programmable Sequential Multi-Step Recipe function. |
| Safety Features | Safety door interlock, exhaust system, grounded chamber, arc detector, door opening request function, solvent-resistant enclosure, and automatic fire extinguisher system | Supports a secure lab environment while decreasing operational hazards and chemical exposure. High safety standards for people operating the Fluidnatek electrospinning equipment. |
| Compliance | CE compliant and independently verified | The Fluidnatek LE-50 G2 electrospinning machine complies with European regulations on electrical safety and electromagnetic compatibility. It reinforces reliability across laboratory setups, educational settings, and professional research applications. |
The Fluidnatek LE-50 G2 is a benchtop lab-scale electrospinning and electrospraying platform designed for advanced R&D, small-batch production, and process development, with a great flexibility and versatility for research at the time it provides a tight process control, for consistent and reproducible results every time. It can be configured with optional environmental control and advanced spinning technologies to support a wide range of applications, enabling to take your research to the next level.
The Fluidnatek LE-50 G2 supports method development, process optimization, and reproducible recipe building. Achieving reproducible results and being able of providing data-driven evidences of an optimized, stable electrospinning process that can be potentially scaled up, definitely helps research teams to move efficiently from initial concept towards larger-scale work, de-risking the project from the beginning and presenting a much higher level of certainty.
Yes. The Fluidnatek LE-50 G2 supports the creation of reproducible processes that can form the basis for future medical devices and pharmaceutical development, either based on electrospun fibers or electrosprayed particles. The Fluidnatek LE-50 G2 electrospinning machine also offers a hygienic design and ultra-clean environment in the spinning chamber, as well as advanced data collection tools to support data-driven results, what are key requirements for biomedical and pharmaceutical applications too.
It offers an unparalleled balance of process control and research flexibility, making it suitable for rigorous, professional electrospinning development and process optimization, and the creation of robust recipes that can be reused and scaled up later on.
The optional ECU (Environmental Control Unit) regulates chamber temperature from 18 to 45°C (±1°C stability around the environmental setpoint) and relative humidity from 10 to 80% RH (±3% stability around the environmental setpoint), helping substantially to improve process reproducibility and to expand the range of processable materials. The lack of environmental control or instability at it, leads unavoidably to lack of consistency and reproducibility of results. This is because all materials are sensitive to environmental conditions, meaning different environmental conditions in the electrosinning chamber will generate different morphologies for electrospun or electrosprayed materials, different uniformities, etc. It is not only about having stable conditions of temperature and relative humidity, but also about being able to adjust the values of both variables in the spinning chamber, since every specific process requires specific optimized conditions for temperature and humidity.
Yes. Recipes or processes developed on the Fluidnatek LE-50 G2 can be transferred to larger Fluidnatek platforms, supporting scale-up and future manufacturing, thus guaranteeing process continuity.
The Fluidnatek LE-50 G2 electrospinning platform supports research teams that need experimental freedom and great flexibility at research without sacrificing control. It is built for method development, optimization, and reproducibility, helping users move from concept to a validated process more efficiently.
Stable environmental control improves consistency across runs and helps researchers focus on formulation rather than external variation. That is essential when comparing recipes or transferring work between different teams and labs.
The optional Environmental Control Unit (ECU) regulates chamber temperature (18–45°C, ±1°C) and relative humidity (10–80%, ±3%), helping improve reproducibility and expand the range of processable materials. By conditioning air before it enters the chamber and working in tandem with the actively regulated exhaust system, the ECU helps maintain a stable spinning environment.
Incoming air is purified via an integrated HEPA filter, helping maintain a clean environment in the electrospinning chamber suitable for the manufacture of medical and pharmaceutical devices. The ECU can be installed remotely at the customer facility and connected through insulated ducting.
Real-time measurement of the electrospinning process gives immediate process feedback and reduces the number of trial-and-error iterations. It supports faster optimization while maintaining a clear link between settings and fiber morphology.
The Fluidnatek LE-50 G2 electrospinning machine supports recipe building that can be transferred to larger Fluidnatek equipment, helping maintain process continuity from lab development toward manufacturing.
Recipes developed on the Fluidnatek LE-50 G2 can be transferred to the Fluidnatek LE-500 scale-up and manufacturing platform, supporting continuity across development and scale-up while helping preserve the key fiber characteristics established during process development. From Lab to Fab directly within the Fluidnatek electrospinning equipment range.
For medical applications, consistency and traceability are essential. Fluidnatek LE-50 G2 helps establish reproducible processes that can support future medical and pharmaceutical development.
The Fluidnatek LE-50 G2 can be supported with documentation and validation services for regulated environments, depending on project requirements. Bioinicia Fluidnatek offers validation services such as FAT/SAT, DQ (Design Qualification), and on-site IQ/OQ (Installation Qualification and Operational Qualification), and even PQ (Performance Qualification) if needed, and additional qualification services may be available upon request.
Beyond compliance, the Fluidnatek LE-50 G2 is designed for long-term versatility. The system features a modular architecture that allows for straightforward evolution:
Whether you are navigating regulated development pathways or expanding your research capabilities, the Fluidnatek LE-50 G2 provides the documentation support and hardware flexibility to grow with your project.
Environmental control can help improve process consistency and reproducibility. With the optional ECU (Environmental Control Unit), the Fluidnatek LE-50 G2 regulates chamber temperature from 18 to 45°C (±1°C accuracy) and relative humidity from 10 to 80% RH (±3% accuracy), depending on operating conditions.
Recipes developed on the Fluidnatek LE-50 G2 can be transferred to the Fluidnatek LE-500 scale-up and manufacturing platform, supporting process continuity from lab development toward manufacturing.
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