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The electrospinning technique is also advancing in different applications in the pharmaceutical field relating electrospinning drug delivery, but electrospraying also offers very interesting solutions for this sector.

There are several properties of these techniques that make them highly suitable for pharmaceutical applications:

Electrospun structures can have a high surface area (in the case of thin films and very thin films), making them ideal for a highly efficient, controlled drug release. Likewise in the case of particles, electrospraying can be used to obtain a nanometric size, even if the particles are in turn inserted into a larger vehicle or platform (e.g. micrometric), which also makes controlled drug release extremely efficient. Drug delivery with electrospinning is the most common application.

Electrospinning applications in drug delivery are gaining traction due to their versatility and efficacy. This approach allows for the creation of structures suitable for various biomedical applications. The high surface area to volume ratio of electrospun fibers makes them ideal for drug delivery, enabling sustained and controlled release of the pharmaceutical active ingredients.

Depending on the materials selected and the type of structure developed, electrospinning and electrospraying can be used for very good matching of the release profile required for a particular application, and to establish a target for the area of the body where release of the API is required (e.g. in an area of the intestine, etc.).

Using electrospinning for drug delivery or electrospraying will depend on the application requirements, including the administration mode (oral, transdermal, intranasal, parenteral…)

The electrospinning and electrospraying processes themselves, given their particularity, can ensure that APIs remain sufficiently amorphous, which may increase the dissolution rate and the permeability of the API, which in turn may often result in greater biocompatibility.

If this is achieved, it represents a huge benefit for the product and for the pharmaceutical industry. One more advantage of electrospinning in drug delivery.

Electrospinning applications in drug delivery and tissue engineering have also shown promise in enhancing drug solubility and bioavailability. The ability to incorporate drugs into biocompatible fibers or particles, and to control their release rates, opens up new pathways in personalized medicine and targeted therapies.

Electrospinning can be used to create fibre-based membranes or sheets with which to produce transdermal and transmucosal patches for different pharmaceutical applications, with the API being released into the bloodstream.

However, if electrospraying is used, particles (i.e. powder) are created that can be used to press and produce tableting for oral intake, or powder in solution for inhalation, or even intravenously (injectable).

Electrospinning in pharmaceutical manufacturing brings numerous advantages, particularly in the creation of drug delivery systems. Electrospinning allows for high control over fiber size and morphology as well as area density, enhancing the effectiveness of electrospinning in drug delivery. This technique enables the encapsulation of drugs within nanofibers (or particles in the case of electrospraying), providing a controlled release mechanism.

Lab scale electrospinning demonstrates the feasibility and adaptability of this technique in a more controlled environment, allowing researchers to fine-tune parameters for optimal drug delivery. This approach is essential for experimental validation and the development of prototypes before scaling up to industrial production.

Moreover, electrospinning in pharmaceutical manufacturing can improve in some cases drug solubility and bioavailability. Electrospinning drug delivery systems have the potential to revolutionize treatments, offering targeted, efficient, and controlled drug distribution, thus underscoring the valuable role of electrospinning in pharmaceutical manufacturing.

Lab scale electrospinning plays a crucial role in the development and optimization of electrospinning drug delivery systems. It allows for precise control over the electrospinning parameters, facilitating the production of fibers with desired characteristics for specific drug delivery applications.

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