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The revolution of cosmetics: new success of the fluidnatek technology for the production of ultrathin fibers by electrospinning

Innovative cosmetic products co-developed by CSIC and Bioinicia: more sustainable and composed only of active ingredients, without excipients and additives: Pure Cosmetics is here!

Patented technology is able to encapsulate compounds in ultra-thin fibers that melt on contact with the skin.

These innovative cosmetic products based on ultra-thin fibers are already available on the market.

Spanish Council for Scientific Research – CSIC, the network of the most excellent research institutes in Spain, together with the company Bioinicia, CDMO of the Bioinicia Group specialized in the development and manufacture of medical, pharmaceutical and cosmetic products using ultrathin fibers (electrospinning) and particles  (electrospraying), have jointly patented a technology that makes it possible to create cosmetic products, composed entirely of active ingredients with proven efficacy in vivo tests. Using this technique, the ingredients are encapsulated in ultra-thin, water-soluble fibers, which in turn are also composed of cosmetic substances. The technology makes it possible to dispense with all the excipients, conservatives, and additives of conventional cosmetics, while maximizing the penetration and efficacy of the active ingredients.

All these cosmetic products based on highly innovative electrospun fiber-based membranes, which achieve a higher penetration of active ingredients than other conventional cosmetic products, are being manufactured excellently using Fluidnatek electrospinning equipment. More specifically, the process was successfully developed and scaled up using a Fluidnatek LE-500 platform (pilot-production plant), while full-scale manufacturing is taking place using Fluidnatek HT industrial line for mass production.

Using this technology, CSIC and Bioinicia -through its brand Bioinicia Cosmetics– have developed a new line of 100% natural and vegan cosmetic products for the care and improvement of skin health. “They are composed solely of bioactive ingredients, creating a new generation of cosmetics: Pure Cosmetics”, says Dr. José María Lagarón, CSIC researcher at the Institute of Agrochemistry and Food Technology (IATA) in Valencia, Spain.

Technology is based on the electro-hydrodynamic processing of the technical effect Fiber Boost by electrospinning, which increases the penetration of the active ingredients by more than ten times. These fibers are 100 times thinner than the thickness of a human hair and melt instantly on contact with the skin, providing a clearly noticeable cosmetic effect in just three seconds of application.

“Its double action mechanism is the key”, says Dr. José María Lagarón. “The ultra-thin fibers adhere and adapt perfectly to the skin’s relief and deliver the active ingredients more homogeneously and effectively. In fact, we have measured that some bioactives penetrate up to 10 times more than in conventional liquid formulations”, he explains. “In addition, the active ingredients are protected within the fibers, embedded in the fibers, keeping all their properties intact and maximizing their efficacy”, he says.

Triple conquest of sustainability in cosmetics

While maximizing the penetration and efficacy of active ingredients, the technology also makes it possible to dispense with all the excipients, conservatives and additives that are necessary to stabilize conventional cosmetics, but which nevertheless provide no benefit to the consumer. “This entails a triple conquer when it comes to sustainability in cosmetics”, Dr. Lagarón points out.

Success of Fluidnatek electrospinning technology

Once again, another real, commercially available electrospun product is manufactured on a large scale using Fluidnatek electrospinning equipment. In this case in the field of cosmetics, although electrospun products have previously been developed in the biomedical, pharmaceutical and filtration fields using Fluidnatek electrospinning platforms. It is a further demonstration of the reliability, consistency, and scalability of Fluidnatek technology to produce nanofiber-based products with a wide range of materials and solvents. Fluidnatek is therefore proud to celebrate this milestone, and we wish Bioinicia and CSIC every success in this new venture in the cosmetics sector.

Bipolar Membranes with 3D Electrospun Junction and Polymeric Catalyst for Energy applications: Hydrogen production…

The aim of this paper is to investigate the use of 3D membrane junctions obtained by electrospinning to improve the catalytic process in bipolar membranes (BPMs) used in water dissociation processes. For this purpose, bipolar membranes with 2D junctions manufactured by lamination are compared with 3D entangled junctions manufactured by electrospinning, using the same polymers for the anionic and cationic layer. In addition, the use of the P4VP polymer as a catalyst for the reaction has been investigated.


Bipolar membranes (BPMs) are a type of membrane that allows ion exchange. BPMs are used to dissociate water in many electrodialysis-based processes, resulting in hydroxides (OH-) and protons (H+) from a neutral solution. Industrial applications of BPMs include the production and purification of acids and bases, CO2 capture, flow batteries and fuel cells, among others.
BPMs are composed of two adjacent charged layers: an anion exchange layer (AEL) and a cation exchange layer (CEL), which are bonded by different techniques. The contact surface between the two exchange layers is called the membrane junction. This junction is generally two-dimensional (2D) and is where the electrocatalytic process of water dissociation takes place.
Conventional BPMs are manufactured by alternating successive layers of anion and cation exchange, which are bonded or pressed together at high pressures and temperatures. BPMs can also be made by melting the different anion and cation exchange layers in a controlled and sequential manner.
Current BPMs have certain limitations, such as low water dissociation rate and poor stability under adverse conditions. To overcome these limitations, the authors of this publication propose to fabricate the membrane junctions of the BPMs by electrospinning. In this case, nanofibers of different polymeric materials used in the anionic and cationic layers are deposited at the membrane junction to increase the contact region between the exchange layers. This generates a three-dimensional (3D) entangled and open structure that facilitates the transport of water within the BPM, thereby increasing the efficiency of the dissociation process. In addition, they also propose the use of polymeric catalysts, particularly P4VP.

Materials and methods

Two different types of polymers were used to manufacture the membranes. The polymer used as cation exchanger was SPEEK (sulphonated poly(ether ether ketone)). The polymer used as an anion exchanger was FAA-3. In both cases, the solvent used was DMAc (dimethylacetamide). On the other hand, there are different catalysts that can be used together with BPM to accelerate the water dissociation process. In this work, the use of P4VP (poly(4-vinylpyrrolidine)) as a catalyst has been investigated by incorporating it into the membrane junction of some of the BPMs manufactured.
Specifically, 5 different types of BPMs have been manufactured in this research work:
– 2 BPMs with 2D junction by lamination and hot pressing: one without catalyst, and the other with P4VP electro-stretched into the bond before lamination.
– 3 BPMs with 3D entangled junction by electrospinning and subsequent hot pressing: one without catalyst, one with 7.7% wt of P4VP in the FAA-3 fibers at the juction, and one with 15% wt of P4VP in the FAA-3 fibers, both at the junction and at the AEL.
The electrospinning equipment used to manufacture the BPMs with 3D bonding was a Fluidnatek LE-50 equipped with two independent emitters mounted on two translation axes for the simultaneous electrospinning of the SPEEK and FAA-3 solutions. The equipment also incorporated an environmental control unit (ECU) to establish and precisely maintain the required temperature and humidity conditions during the process.
The fabricated membranes were morphologically characterized using SEM (scanning electron microscopy) images and EDS (energy dispersive X-ray spectroscopy). The characterization of the electrochemical properties was carried out using a homemade five-compartment test cell that allowed the measurement of current efficiency and OCV (open-circuit voltage).


The obtained results show that the electrospinning fabricated BPMs with 3D junction offer a higher performance in the water dissociation process compared to the BPMs with laminated 2D junctions, since the entangled 3D juctions offer a higher specific exchange surface for dissociation. On the other hand, the results also show that the use of a polymer catalyst such as P4VP improves the performance of the water dissociation process due to the increase in the number of additional active sites for the reaction.
The increased performance and stability in the water dissociation process offered by 3D BPMs fabricated by electrospinning make them ideal candidates for applications such as desalination, hydrogen production and energy storage.

ACS Appl. Energy Mater. 2021, 4, 3724-3736


The aim of this study is to characterise, using non-invasive techniques, three-dimensional sponges made of electrospun PLA fibres for its use in controlled drug release applications. This type of sponge is novel, so the fundamental processes that occur inside it concerning the absorption of liquids and their subsequent release are still unknown.



The development of novel and alternative controlled drug delivery systems is a very active area of research in the pharmaceutical industry. Currently, controlled drug delivery is done through preformed implants, microparticles and in-situ formed implants. Problems with these systems include complex manufacturing, undesirable release profiles, autocatalytic degradation of polymers leading to very acidic microenvironments (pH around 2) and, in some cases, the need to inject organic solvents into the body for implant formation.

A challenging alternative is the use of Polymer Fiber Sponges (PFS), which are highly porous three-dimensional scaffolds made from polymer fibers obtained by electrospinning. Electrospinning is a very versatile tool for the creation of scaffolds that allows, from polymeric solutions, to obtain a wide variety of electrospun fibers in which it is possible to adjust their size and distribution, as well as the porosity of the structure. However, they are generally produced in the form of thin two-dimensional (2D) sheets. This results in a structure with a low specific pore volume, requiring larger incisions to place the implants at the treatment site, which is problematic. As an alternative solution, it is proposed to fabricate PFSs by freeze-drying using fibers obtained by electrospinning. This process makes it possible to obtain a three-dimensional (3D) matrix that is compact, stable, with adjustable porosity and interconnected in all directions, all qualities that favor the loading and subsequent release of drugs. In addition, this manufacturing technique allows both the size of the fiber and the size of the sponge itself to be adjusted and can be created from different materials, including degradable polymers.

Drug loading into the sponge can be done either by incorporating the drug into the solution used during electrospinning, so that it forms part of the fibers themselves, or by incorporating it into the pores of the PFS once it has been created. The choice of one method or the other will depend on the nature of the drug itself and the desired release profile.

In PFSs, the parameters that determine their drug retention and release capacity are their permeability and hydrophobicity. However, the fundamental mechanisms that occur within PFSs during these drug loading and release processes are still poorly understood. Therefore, the aim of this scientific publication is to investigate these processes in more detail using non-invasive techniques.


Materials and methods

The characterized PFS was fabricated from PLA (polylactide acid) fibers obtained by electrospinning. To achieve the cylindrical shape, the fibers were formed by cold drying, resulting in a PFS with a density of 12.5 mg/cm3, a height of 6.1 mm and a diameter of 8.0 mm. To adjust the drug release profile, the PFS was coated with PPX (poly(para xylylene)) by chemical vapor deposition (CVD), increasing its final density to 28 mg/cm3.

The non-invasive techniques used to characterize the liquid absorption and subsequent release in the PFS were:

  • µCT (micro Computed Tomography) to record 3D images of the distribution of liquid and air inside the PFS during drug loading and release.
  • NMR (Nuclear Magnetic Resonance) to study diffusion coefficients.
  • EPR (Electron Paramagnetic Resonance) spectroscopy and imaging to record the amount of liquid that the PFS was able to absorb over time.



From a mechanical point of view, the PFSs are able to maintain their shape and elasticity in all tests carried out, both in dry and liquid-loaded conditions. Furthermore, the results show that the PFSs retain liquids within their structure and preserve the drug in a given geometry.

The results also show that the properties of PFSs can be adjusted through the addition of excipients and coatings during their manufacture, so that the desired drug release characteristics can be achieved.

Therefore, PFSs made by electrospinning fibers are shown to be a very versatile support for controlled drug delivery in various applications, such as pharmaceuticals or tissue engineering.




Noninvasive characterization (EPR, μCT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery

International Journal of Pharmaceutics: X 2 (2020) 100055



Ceramic materials are widely known for their high temperature resistance, chemical stability, and high mechanical and electrical properties. Ceramic materials come in a variety of forms, including nanoparticles (0D), nanofibers (1D), thin films or coatings (2D) and bulk ceramics (3D).

In recent years, electrospinning for ceramic materials has attracted interest for its ability to produce ceramic nanofibers with unique properties.

Electrospinning with ceramic materials

In the ceramic materials context, and because they are not amenable to direct dissolution, the electrospinning process to obtain ceramic nanofibers typically involves the incorporation of a ceramic precursor into a polymeric solution (using a polymer with a high capacity to be stably processed by electrospinning). The main steps for obtaining ceramic nanofibers are:

  • Preparation of the polymer solution: since a solution made only with ceramic precursors does not have sufficient viscosity to form a jet during the electrospinning process (and viscosity is one of the essential parameters in the electrospinning process), a compatible polymer is usually added. The choice of polymer and ceramic precursor, as well as their concentration and ratio, depends on the desired properties of the final ceramic nanofibers. Another option is to use the sol-gel process, which includes a polymerization step.

  • Electrospinning process: the solution is loaded into a syringe (in the case of laboratory-scale electrospinning equipment), and a high voltage is applied between the needle and the collector. The electric field causes the solution to form what is known as a Taylor cone at the tip of the needle, which in turn generates a jet. This jet is stretched and, as it travels between emitter and collector, the solvent evaporates, and solidified nanofibers are generated. At this point, the ceramic precursor is embedded in the polymer nanofibers.

  • Heat treatment (post-processing): electrospun ceramic nanofibers are often subjected to calcination treatment in the form of post pyrolysis, hydrothermal and carbothermal processes. These treatments remove the polymer, so that the resulting nanofibers are composed exclusively of the ceramic material. These treatments also remove the polymer, so that the resulting nanofibers are composed exclusively of the ceramic material.

Ceramic materials and precursors

There are several ceramic materials that have been successfully processed by electrospinning, allowing the number of applications to continue to grow. Examples of ceramic materials include oxides (e.g. TiO2, ZnO, SiO2), carbides (e.g. SiC), nitrides (e.g. BN), and composites. The choice of ceramic precursor influences the properties of the resulting nanofibers, such as their mechanical strength, electrical conductivity and thermal stability.

Composite fibers combining polymers with ceramic materials are attracting a lot of interest. These composites often have improved mechanical, thermal or electrical properties compared to their individual components.

Polymer-ceramic composites: by carefully selecting polymers and ceramic precursors, researchers create composites that exploit the desirable properties of both components. The electrospinning technique can generate nanofibers from polymer-ceramic composites. These composites have applications in a wide range of fields, from aerospace to electronics.

Carbon-ceramic composites: electrospinning has played a key role in producing carbon-ceramic composites. These materials show improved mechanical and thermal stability, making them suitable for high temperature applications.

Ceramic nanofibers applications with electrospinning

Some of their applications include:

  • Catalysis: ceramic nanofibers, with their high surface area, are an excellent platform for catalytic applications. Catalysis tests performed on electrospun ceramic nanofibers show increased activity and stability, making them valuable for industrial applications.
  • Sensors: electrospun ceramic nanofibers are being investigated for use in sensors due to their high surface area to volume ratio. They can be used in gas and moisture sensors, and in biosensors, as they have a high sensitivity to changes in the environment.
  • Energy storage: ceramic nanofibers play a key role in energy storage devices such as lithium-ion batteries and supercapacitors. Their unique structure facilitates fast charge/discharge cycles, improving the performance of these devices. Electrospinning nanofiber membranes usually generates high energy density and good electronic transfer. This is why electrospinning is also emerging in energy-related applications.
  • Tissue engineering: In the biomedical field, ceramic nanofibers are being investigated for tissue engineering applications. These fibers can provide a scaffold that replicates the extracellular matrix, promoting cell adhesion and growth. Electrospinning is one of the techniques being explored most recently in the field of tissue engineering.
  • Filtration: the high porosity and small pore size of ceramic nanofibers produced by electrospinning make them suitable for certain filtration applications. They have been successfully employed in air and water filtration systems, demonstrating their ability and efficiency to separate particles.

Challenges and sustainability

Among the main challenges in obtaining ceramic nanofibers is achieving a homogeneous distribution of the ceramic precursor within the polymer matrix, as this is critical for the formation of uniform ceramic nanofibers. Researchers are currently facing challenges related to phase separation during the electrospinning process to improve the overall quality of the nanofibers.

On the other hand, researchers are exploring the use of eco-friendly ceramic precursors with the aim of developing sustainable methods for large-scale production while reducing environmental impact.



Electrospinning has emerged as a particularly suitable technique for producing ceramic nanofibers due to its low cost, ease of preparation of the solution containing the ceramic precursor and the polymer, and its ability to generate solid and hollow nanofibers. The properties of nanofibers obtained by electrospinning are superior to their bulk equivalent due to their low weight, as well as their porous structure and high surface area.

The applications of ceramic nanofibers are broad, ranging from catalysis and energy storage to tissue engineering. The unique properties exhibited by ceramic nanofibers continue to drive innovation in various fields. Ongoing research is addressing challenges related to dissolution formulation, phase separation and process scale-up. More sustainable alternatives and eco-friendly applications are also being explored, ensuring the continued growth of electrospinning in the field of ceramic materials.

At Bioinicia Group, we have experience in the processing of some ceramic materials by electrospinning. Also, some of our customers, users of Fluidnatek electrospinning equipment, are specialists in ceramic applications with electrospinning nanofibers, with a positive and satisfactory result of the use of Fluidnatek technology for electrospinning and electrospraying.


[1] B. Sahoo et al., “Electrospinning of functional ceramic nanofibers”, Open Ceramics 11 (2022) 100291.

[2] H. Esfahani et al., “Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications”, Materials 2017, 10, 1238.

Ophthalmologic applications of electrospinning


In recent years, electrospinning has aroused much interest in the biomedical field of ophthalmology due to the possibilities it offers for the treatment of various pathologies affecting the eye. Especially with the proliferation of available electrospinning biomaterials.

Electrospinning is a fiber production technique based on the use of powerful electric fields, which are applied to a solution formed by one or more polymers (and alternatively other types of materials as well, including even biological materials) and one or more solvents. This solution, usually contained in a syringe-type container when working at laboratory scale, is pumped through a needle or capillary. In electrospinning, a high voltage is applied to the tip of the needle, so that the accumulation of electrical charges on the surface of the droplet produces an electrical repulsion effect between the particles of the solution, until finally the electrical force overcomes the surface tension of the droplet, stretching it to generate a jet. As the jet moves toward the collector, which is at zero or negative voltage, the solvent evaporates, generating polymer fibers that are eventually deposited onto the collector.

The fibers generated by electrospinning can vary from the nanometer and micrometer range according to the interest of each particular application, which is very interesting for biomedical applications, since the proper selection of the polymer allows the creation of fibrillar structures that resemble the extracellular matrix (ECM) in size and arrangement. It is possible to use different electrospinning biomaterials: biopolymers, bioabsorbable polymers, non-bioabsorbable polymers, etc, as long as they are of biomedical grade.

Electrospinning applications in ophthalmology

Vision is one of the five primary senses of the human being, so any pathology affecting the ocular system has a great impact on people’s quality of life. According to a report by the World Health Organization, at least 2.2 billion people in the world suffer from vision-related pathologies [1]. Of these, it is estimated that almost 1 billion could be preventable or treatable [2].

In this context, fibers generated from electrospinning biomaterials offer a number of advantages in the development of new ocular therapies. Nanofibers offer a very high surface area, which is advantageous for tissue regeneration and controlled drug release applications. In addition, the adjustable porosity of nanofiber matrices favours cell growth and proliferation and does not interfere with tissue respiration and gas exchange.

Main applications of electrospinning in ophthalmology

  1. Controlled drug delivery

Electrospinning is being used to create nanofiber arrays in which drugs and active ingredients are incorporated. The spatial configuration of the nanofibers allows a sustained and controlled release of drugs into the eye in a very efficient manner. The nanofiber matrix is based on appropriately selected electrospinning biomaterials as required by the specific application.

For example, in the treatment of glaucoma, the controlled release of drugs can reduce intraocular pressure for a longer period of time. On the other hand, if the nanofiber matrix is loaded with anti-inflammatory agents, pathologies such as uveitis or post-operative inflammation can be treated more effectively. If antibiotics are used, corneal infections can be treated.

  1. Ocular tissue engineering

Nanofiber arrays generated with electrospinning biomaterials are the ideal support for ocular tissue engineering due to their similarity to the extracellular matrix, thus promoting cell adhesion and proliferation, as well as regeneration of damaged tissues in the eye. These nanofiber matrices can replace damaged corneal tissue, as well as contribute to the regeneration of retinal and optic nerves.

  1. Ocular medical devices

Ocular medical devices, such as intraocular lenses, artificial corneal implants, or even contact lenses, can benefit from the possibility of depositing a thin layer of nanofibers on or around them. In this way, this nanofiber layer will act as an interface between the medical device and the eye, stimulating the growth of cells around the device, thus increasing its biocompatibility and reducing the possibility of rejection. In intraocular devices, this nanofiber interface and subsequent cell proliferation also helps to better fix the implant inside the eye.


Electrospinning is a very versatile technique that has numerous applications in the field of ophthalmology due to its ability to control the characteristics of the nanofibers obtained. These applications are constantly evolving and improving thanks to the new electrospinning biomaterials that are becoming increasingly available. Advances in electrospinning and its applications in ophthalmology will provide researchers and physicians with a powerful tool to improve the quality of life of people with ocular pathologies.



[1] D. Sakpal et al., “Recent advancements in polymeric nanofibers for ophthalmic drug delivery

and ophthalmic tissue engineering,” in Biomaterials Advances 141 (2022) 213124.

[2] D. Mishra et al., “Ocular application of electrospun materials for drug delivery and cellular

therapies,” in Drug Discovery Today vol. 28, num. 9, 2023.

Electrospun scaffolds for kidney tissue engineering: on the way towards kidney organoids

Chronic kidney disease is one of the deadliest diseases all around the world. Current healing methods mostly rely on transplantation and dialysis. Engineering of kidney tissues in vitro from induced pluripotent stem cells could provide a solution by restoring the function of damaged kidneys. Electrospinning is a technique that has shown promise in the development of physiological microenvironments of several tissues and could be applied in the engineering of kidney tissues as well.

So far several approaches with electrospinning were attempted. Synthetic polymers such as PCL, PLA and PVOH have been explored in the manufacturing of fibers that promote the proliferation and cell-to-cell interactions of kidney cells. Also natural polymers like silk fibroin have been explored alone and in combination with synthetic polymers promoting the differentiation of podocytes and tubular specific cells. Natural polymers are highly interesting but in many cases they do not provide the mechanical resistance required, that is the reason for combining with synthetic polymers which can balance the lack of resistance.

Furthermore, the use of the electrospinning technique in combination with other manufacturing methods such as bioprinting are highly promising aiming to develop more organized, mature and reproducible kidney organoids. It is important to take into account that kidney cells’ behaviour is strongly dictated by the complex 3D microenvironment. Kidney organoids derived from human induced pluripotent stem cells can be attractive 3D models for different purposes, including to model kidney embryonic development, kidney disease, and renal regeneration. The electrospinning technique is also compatible with live cells encapsulating them in the desired environment.

Electrospinning have been demonstrated to be a promising technique to develop kidney tissues in vitro. However it is still a challenge the lack of knowledge in the specific stimulus required to create kidney organoids. In essence, electrospinning for tissue engineering offers significant benefits due to its unique ability to create biomimetic structures. It can fabricate fibrous scaffolds that closely resemble the extracellular matrix of tissues, promoting cell growth and tissue regeneration. Furthermore, electrospinning for tissue engineering applications allows control over fiber diameter and porosity, aiding in the customization of scaffolds. Electrospinning for tissue engineering has shown to be promising in areas like bone, skin, organs and vascular grafts. Its versatility enhances the potential of electrospinning for tissue engineering applications, marking a significant step forward in regenerative medicine.

Further information can be found in the paper written by Claudia C. Miranda, Mariana Ramalho, Mariana Moço, Joaquim Cabral, Federico Castelo Ferreira and Paola Sanjuan-Alberte from Universidade de Lisboa.

We invite you to our webinar “Elastin-Based Nanofibers for Advanced Wound Care: Innovation Driven by Electrospinning”

From Bioinicia Fluidnatek, we would like to invite you to our highly informative Webinar in collaboration with the German biomedical company, matrihealth.

Date: November 22nd, 2023.
Time: 5 p.m. CET / 11 a.m. ET / 8 a.m. PT.
Register on this link:


The extracellular matrix (ECM) is composed of a fibrous network of structural proteins that enhance tissue mechanical properties and offer cellular support. Elastin, a pivotal structural protein within the ECM, is the main component of elastic fibers, and responsible for the elasticity and resilience of tissues and organs. However, elastin is not replenished throughout life, leading to tissue degeneration and loss of function. In response to this challenge, we have devised biomaterials with customizable mechanical properties as a promising solution to counteract the age- and injury-related decline in skin function. We isolated and processed elastin through a proprietary and industrially scalable process to develop composite elastin/collagen nonwoven materials using electrospinning and chemical crosslinking. Processed elastin was successfully integrated into electrospun nonwovens in high amounts up to 90%. Elastin significantly reduces the elastic modulus of the nanofibers while increasing the fleece porosity. These fully absorbable materials exhibited non-cytotoxicity, low irritative potential, and proved to be excellent scaffolds for cell culturing. Furthermore, endotoxin levels for processed elastin and cross-linked nonwovens were both found to be below 10 EU/g and 5 EU/g, respectively, and the material does not cause averse tissue reactions after implantation. Our work has yielded a versatile platform for the industrial-scale, cost-effective production of elastin and tunable nonwoven materials produced by electrospinning for a wide range of biomedical applications.

About the expert

Tobias Hedtke is the CTO and co-founder of matrihealth. He studied biochemistry at Martin Luther University Halle-Wittenberg and received his Master’s degree in 2016. Since 2017, he has been a research associate at the Fraunhofer Institute for Microstructure of Materials and Systems IMWS in Halle (Saale), Germany specializing in the development and characterization of protein-based biomaterials. He is pursuing his PhD in elucidating the molecular structure of elastin and is using these new insights to develop novel elastin-based biomaterials. Since October 2022, he has been responsible for technology, production, and product development at matrihealth GmbH.

About matrihealth

matrihealth GmbH is a life science start-up founded in October 2022 as a spin-off from the Fraunhofer Institute for Microstructure of Materials and Systems IMWS in Halle (Saale), Germany. matrihealth specializes in the isolation and processing of elastin, which will be sold as a raw material in the R&D, cosmetics, nutrition, and medical market sectors. For this purpose, the matrihealth team has developed a proprietary and industrially scalable process that enables the cost-effective production of this high-quality raw material. Another focus of matrihealth is the development of biomaterials for the treatment of complex and chronic wounds, which will be further developed into wound treatment products in the future.

We look forward to welcoming you.

Bioinicia Fluidnatek – Sponsors at Berlin Symposium on Tissue Regeneration 2023!

We are excited to announce that Bioinicia Fluidnatek will be present at the BSRT – Tissue Regeneration Symposium 2023 in Berlin, Germany, as a sponsor of the event from 6th to 8th December, 2023. We will be happy to attend anyone interested in electrospinning for biomedical applications.

This event is a unique opportunity to acquire new knowledge in various disciplines related to tissue regeneration from expert speakers who will discuss the challenges facing regenerative medicine with a focus on enhancing tissue regeneration.

We are excited to share ideas, learn from other experts and discuss what we have learned, network with leaders and innovators and share the latest developments of our premium equipments in electrospinning and electrospraying techniques, which produce electrospun materials, for biomedical research.

We look forward to seeing you there, on the Hallway!


Bioinicia Fluidnatek and The Electrospinning Company further strengthen their collaboration.

Bioinicia Fluidnatek and The Electrospinning Company Ltd. collaborate to provide the medical device industry with unmatched levels of process development and manufacturing capability for electrospun materials and implantable devices. ELECTROSPINNING uses the FLUIDNATEK® electrospinning and electrospraying equipment platform for its biomaterial development and for its custom design, development, and manufacturing services.

The Electrospinning Company facility & Fluidnateck Equipment

FLUIDNATEK & ELECTROSPINNING have been working together since 2017, combining expertise in polymer chemistry and biomaterial design with mechanical and software engineering to deliver innovative, safe, and reliable solutions to medical device product developers. ELECTROSPINNING operates a series of FLUIDNATEK electrospinning machines in its class VII cleanroom facilities which FLUIDNATEK supports with a full maintenance and calibration service to ensure compliance with medical device quality standards.

The Companies are strengthening their partnership with continual improvement projects to customize electrospinning platforms to specific product requirements and to develop data collection and analytical tools for traceability under the ISO13485 requirements for medical device manufacturing and statistical process control. In addition, FLUIDNATEK is supporting ELECTROSPINNING with the development of automated production processes to improve consistency and cost as volumes scale.

Amongst its FLUIDNATEK’s electrospinning equipment, ELECTROSPINNING is using FLUIDNATEK’s BioTubing platform specifically engineered for the production of electrospun tubular structures to be used for structural heart and peripheral vascular interventions. This technology platform address the need for suture-less bonding of medical textiles to a wide range of stent and occluders. The combination of state-of-the-art equipment by FLUIDNATEK and a decade of experience in electrospun non-woven biomaterials by ELECTROSPINNING unlocks the development and manufacturing of a new generation of medical devices now and in the future.

The Electrospinning Company R&D Scietists

About Bioinicia Fluidnatek

The Bioinicia Group based in Valencia, Spain, specializes in electrospinning & electrospraying processes with a focus on pharmaceuticals (drug delivery platforms), biomedical, cosmetics, filtration, and nutraceuticals. Under the Fluidnatek® and Spinbox® brand names, Bioinicia Fluidnatek develops and commercializes electrospinning equipment with a high degree of specialization for the pharmaceutical and biomedical fields.

About The Electrospinning Company

The Electrospinning Company, based on the Harwell Innovation Campus near Oxford in the UK, designs, develops, and manufactures nanofibrous biomaterials for implantable medical devices and regenerative medicine applications. The Company has four technology platforms: Mimetix® resorbable membranes; Kalyptix® non-resorbable membranes; Symatix® bio-synthetic membranes and Coating of medical textiles onto metal and non-metal 3D structures. It offers a range of proprietary materials as well as tailored contract development and manufacturing services, all in validated cleanrooms under ISO 13485 accreditation.