We invite you to our webinar “Elastin-Based Nanofibers for Advanced Wound Care: Innovation Driven by Electrospinning”

From Bioinicia Fluidnatek, we would like to invite you to our highly informative Webinar in collaboration with the German biomedical company, matrihealth.

Date: November 22nd, 2023.
Time: 5 p.m. CET / 11 a.m. ET / 8 a.m. PT.
Register on this link:
https://attendee.gotowebinar.com/register/7522290544659596376?source=Pagina+web+noticias

Abstract

The extracellular matrix (ECM) is composed of a fibrous network of structural proteins that enhance tissue mechanical properties and offer cellular support. Elastin, a pivotal structural protein within the ECM, is the main component of elastic fibers, and responsible for the elasticity and resilience of tissues and organs. However, elastin is not replenished throughout life, leading to tissue degeneration and loss of function. In response to this challenge, we have devised biomaterials with customizable mechanical properties as a promising solution to counteract the age- and injury-related decline in skin function. We isolated and processed elastin through a proprietary and industrially scalable process to develop composite elastin/collagen nonwoven materials using electrospinning and chemical crosslinking. Processed elastin was successfully integrated into electrospun nonwovens in high amounts up to 90%. Elastin significantly reduces the elastic modulus of the nanofibers while increasing the fleece porosity. These fully absorbable materials exhibited non-cytotoxicity, low irritative potential, and proved to be excellent scaffolds for cell culturing. Furthermore, endotoxin levels for processed elastin and cross-linked nonwovens were both found to be below 10 EU/g and 5 EU/g, respectively, and the material does not cause averse tissue reactions after implantation. Our work has yielded a versatile platform for the industrial-scale, cost-effective production of elastin and tunable nonwoven materials produced by electrospinning for a wide range of biomedical applications.

About the expert

Tobias Hedtke is the CTO and co-founder of matrihealth. He studied biochemistry at Martin Luther University Halle-Wittenberg and received his Master’s degree in 2016. Since 2017, he has been a research associate at the Fraunhofer Institute for Microstructure of Materials and Systems IMWS in Halle (Saale), Germany specializing in the development and characterization of protein-based biomaterials. He is pursuing his PhD in elucidating the molecular structure of elastin and is using these new insights to develop novel elastin-based biomaterials. Since October 2022, he has been responsible for technology, production, and product development at matrihealth GmbH.

About matrihealth

matrihealth GmbH is a life science start-up founded in October 2022 as a spin-off from the Fraunhofer Institute for Microstructure of Materials and Systems IMWS in Halle (Saale), Germany. matrihealth specializes in the isolation and processing of elastin, which will be sold as a raw material in the R&D, cosmetics, nutrition, and medical market sectors. For this purpose, the matrihealth team has developed a proprietary and industrially scalable process that enables the cost-effective production of this high-quality raw material. Another focus of matrihealth is the development of biomaterials for the treatment of complex and chronic wounds, which will be further developed into wound treatment products in the future.

www.matrihealth.com

We look forward to welcoming you.

INTERESTED? CONTACT OUR SPECIALISTS!
INTERESTED? CONTACT OUR SPECIALISTS!